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Literature suggests that concomitant use of PPIs with methotrexateprimarily at high dosesee methotrexate prescribing informationmay elevate and prolong serum levels of methotrexate and/or its metabolitepossibly leading to methotrexate toxicitiesIn high-dose methotrexate administration a temporary withdrawal of the PPI may be considered in some patientssee DRUG INTERACTIONS

The safety and effectiveness of NEXIUM in neonates have not been established.

Some conditions are treated with a combination of esomeprazole and antibioticsUse all medications as directed.

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